Dominique Duncan, University of Southern California
2022 AWM Research Symposium
Systems and Control

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx), is a multi-site, international collaboration including a parallel study of humans and an animal model, collecting MRI, EEG, and blood samples. The development of epilepsy after TBI is a multifactorial process and crosses multiple modalities. Without a full understanding of the underlying biological effects, there are currently no cures for epilepsy. This study hopes to address both issues, calling upon data generated and collected at sites spread worldwide among different laboratories, clinical sites, in different formats, and across multicenter preclinical trials. Before these data can even be analyzed, a central platform is needed to standardize these data and provide tools for searching, viewing, annotating, and analyzing them. We have built a centralized data archive that will allow the broader research community to access these shared data in addition to analytic tools to identify and validate biomarkers of epileptogenesis in imaging and electrophysiology as well as in molecular, serological, and tissue data. Besides EpiBioS4Rx, we have also developed other large-scale multimodal data archives, including the Data Archive for the BRAIN Initiative (DABI) and the COVID-19 Data Archive (COVID-ARC) to encourage collaboration and expedite research in these areas.

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