Search Research Symposium Abstracts

Active deformation and tension in the cell membrane is critical for cell movement: computational studies*

Cell motility and spreading require large local deformations and stretch of the lipid bilayer that makes up the cell membrane. Membrane dynamics, namely unfolding of surface projections and exocytosis from intracellular reservoirs to the lipid bilayer, are necessary for these large changes in cell shape (Figard & Sokac, BioArchitecture, 2014). In addition, [Read More...]

Presenter: Magda Stolarska, University of St. Thomas
Authors: Magdalena Stolarska, Aravind Rammohan
Symposium Year: 2022
Session: Recent advances in Cell- and Tissue-Scale Mathematical Modeling of Cancer
Presentation Time: June 18, 2022; 10:15 am

Modeling Cancer Immunotherapies through in silico Trials*

Immunotherapies are a promising new development in treating breast cancer and specifically triple-negative breast cancer (TNBC). In our research we investigate two types of immunotherapies: Cytotoxic T-cell (CTLs) insertion therapy and Chimeric Antigen Receptor (CAR) T-cell therapy using an agent-based model (ABM) of breast cancer development. In CTL [Read More...]

Presenter: Kerri-Ann Norton, Bard College
Authors: Kerri-Ann Norton, Henning Fischel, Tina Giorgadze, Ansel Tessier, and Michael Ventoso
Symposium Year: 2022
Session: Recent advances in Cell- and Tissue-Scale Mathematical Modeling of Cancer
Presentation Time: June 18, 2022; 10:40 am

Reconstructing the metabolic landscape from histology images using a hybrid agent-based model

The tortuous tumor vasculature and irregular cellular architecture can modify the metabolic landscape resulting in heterogeneities in tissue oxygenation. This can influence tumor response to anticancer therapies, i.e., chemotherapy, radiotherapy, and immunotherapy. To examine the distribution of intratumoral metabolites, we developed an in-silico hybrid [Read More...]

Presenter: Maureiq Ojwang', Moffitt Cancer Center
Authors: Maureiq Ojwang' and Kasia Rejniak
Symposium Year: 2022
Session: Recent advances in Cell- and Tissue-Scale Mathematical Modeling of Cancer
Presentation Time: June 18, 2022; 11:05 am

Image-guided mathematical model to predict patient-specific response to neoadjuvant chemotherapy

Patients with locally advanced, triple-negative breast cancer (TNBC) typically receive neoadjuvant chemotherapy (NAT) to downstage the tumor and improve the outcome of subsequent breast conservation surgery. In this study, we integrated quantitative magnetic resonance imaging (MRI) data with biology-based mathematical modeling to address the currently unmet [Read More...]

Presenter: Chengyue Wu, Oden Institute for Computational Engineering and Sciences, UT Austin
Authors: Chengyue Wu, Angela M. Jarrett, Zijian Zhou, Nabil Elshafeey, Beatriz E. Adrada, Rosalind P. Candelaria, Rania Mohamed, Medine Boge, Lei Huo, Jason White, Debu Tripathy, Vicente Valero, Jennifer Litton, Clinton Yam, Jong Bum Son, Jingfei Ma, Gaiane M. Rauch, Thomas E. Yankeelov
Symposium Year: 2022
Session: Recent advances in Cell- and Tissue-Scale Mathematical Modeling of Cancer
Presentation Time: June 18, 2022; 11:30 am