Search Research Symposium Abstracts

Using digitized histology images to assess the hindering effects of hypoxia on T cell infiltration in orthotopic bladder tumors in mice.

Hypoxia is a common feature of solid tumors such as bladder cancers. Mathematical models defined on a cellular level (microscale) of oxygen transport can be used to recreate tissue hypoxia. We designed a hybrid multicell lattice-free agent-based model using continuous oxygen kinetics and discrete cells and vasculature obtained from digitized histology [Read More...]

Presenter: Maureiq Ojwang', Moffitt Cancer Center
Authors: Maureiq Ojwang', Anjun Hu, McKenzie Williams, Sarah Bazargan, Shari Pilon-Thomas, Katarzyna A. Rejniak
Symposium Year: 2023
Session: Multiscale modeling for preclinical and clinical oncology [Organized by Maureiq Ojwang' and Chengyue Wu]
Presentation Time: September 30, 2023; 2:00 pm

Undergraduate Explorations in Cancer Growth and Treatment

Cancer research funding continues to grow because cancer research saves lives. Undergraduate students who have completed an introductory course in ODEs can contribute towards this worldwide goal of understanding how cancer spreads in the body and how cancer may be controlled. In this talk, I will share research projects where students use mathematical [Read More...]

Presenter: Maila Hallare, United States Air Force Academy
Authors: Maila Hallare
Symposium Year: 2023
Session: Multiscale modeling for preclinical and clinical oncology [Organized by Maureiq Ojwang' and Chengyue Wu]
Presentation Time: September 30, 2023; 2:25 pm

Mathematical Modelling of Novel Treatment Strategies in Glioblastomas

Background: Glioblastoma is a deadly brain tumour with a median survival of 15 months. Immunotherapy using immune checkpoint inhibitors (ICIs) has shown promise in other solid tumours, such as melanoma, but clinical trials in glioblastoma have thus far failed. Recent studies showed lasting benefits for those who responded to treatment, suggesting that an [Read More...]

Presenter: Blanche Mongeon, University of Montreal
Authors: Blanche Mongeon, Morgan Craig
Symposium Year: 2023
Session: Multiscale modeling for preclinical and clinical oncology [Organized by Maureiq Ojwang' and Chengyue Wu]
Presentation Time: September 30, 2023; 2:50 pm

Modelling treatment-induced tumor stability via nullclines

Rather than completely eradicating a tumor, there is increasing interest in identifying therapeutic regimens capable of maintaining tumor burden within well-defined boundaries (i.e., so-called stable disease). However, finding such a therapeutic regimen that achieves this goal remains challenging. We are developing a theoretical framework for attacking this [Read More...]

Presenter: Lois C. Okereke, Oden Institute, The University of Texas at Austin
Authors: Lois C. Okereke, Ernesto A. B. F. Lima, Anna G. Sorace, Thomas E. Yankeelov
Symposium Year: 2023
Session: Multiscale modeling for preclinical and clinical oncology [Organized by Maureiq Ojwang' and Chengyue Wu]
Presentation Time: September 30, 2023; 3:15 pm

Patient-Specific Optimization of Catheter Placement for Convection-Enhanced Nanoparticle Delivery in recurrent GBM

Glioblastoma (GBM) is the most common and deadliest of all primary brain cancers. One promising treatment strategy for patients with recurrent GBM is convection-enhanced delivery (CED) of Rhenium-186 (186Re)-nanoliposomes (RNL) to locally deliver large doses of radiation. The success of CED treatment relies on proper catheter placement for therapy delivery [Read More...]

Presenter: Chengyue Wu, Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin
Authors: Chengyue Wu, David A. Hormuth II, Chase Christenson, Michael R. A. Abdelmalik, Ryan T. Woodall, William T Phillips, Thomas J. R. Hughes, Andrew J. Brenner, Thomas E. Yankeelov
Symposium Year: 2023
Session: Multiscale modeling for preclinical and clinical oncology [Organized by Maureiq Ojwang' and Chengyue Wu]
Presentation Time: September 30, 2023; 3:40 pm