Search Research Symposium Abstracts

Mathematical modeling of tissue-specific insulin resistance in adolescent girls with polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) affects approximately 12% of reproductive-aged women and is associated with impaired metabolic health. Quantifying tissue-specific insulin resistance (IR) in adolescent girls with PCOS is vital to understanding disease progression and guiding early interventions. However, the gold standard for quantifying tissue specific IR, [Read More...]

Presenter: Cecilia Diniz Behn, Colorado School of Mines
Authors: Cecilia Diniz Behn, Kai Bartlette, Bryan C. Bergman, Kristen J. Nadeau, Melanie Cree
Symposium Year: 2023
Session: Promoting children's and women's health with mathematical and computational approaches [Organized by Karin Leiderman and Anna Nelson]
Presentation Time: October 1, 2023; 2:00 pm

Studying the Effects of Oral Contraceptives on Coagulation Using a Mathematical Modeling Approach

The use of oral contraceptives (OCs) is known to increase the risk of thrombosis, but the mechanisms underlying this risk and the determinants of the tests that assess this risk are not fully understood. In this study, we used a mathematical model to study the effects of the OC levonorgestrel (lev) on blood clotting. Lev is reported to change the plasma [Read More...]

Presenter: Karin Leiderman, UNC Chapel Hill
Authors: Amy Kent, University of Oxford; Karin Leiderman, University of North Carolina at Chapel Hill; Anna C. Nelson, Duke University; Suzanne Sindi, University of California, Merced; Melissa M. Stadt, University of Waterloo; Lingyun (Ivy) Xiong; Ying Zhang, Brandeis University
Symposium Year: 2023
Session: Promoting children's and women's health with mathematical and computational approaches [Organized by Karin Leiderman and Anna Nelson]
Presentation Time: October 1, 2023; 2:25 pm

Towards a mathematical understanding of ventilator-induced lung injury in preterm rat pups

Approximately 1 % of infants are born extremely preterm and are prone to respiratory distress. Typical treatments are less effective for this group and invasive mechanical ventilation applied as a last resort causes trauma, leading to ventilator-induced lung injury (VILI). Further, maternal infection can cause prenatal and neonatal lung infection, [Read More...]

Presenter: Rayanne Luke, George Mason University
Authors: Rayanne Luke, Gess Kelly, Melissa Stoner, Jordana Esplin O'Brien, Sharon Lubkin, and Laura Ellwein Fix
Symposium Year: 2023
Session: Promoting children's and women's health with mathematical and computational approaches [Organized by Karin Leiderman and Anna Nelson]
Presentation Time: October 1, 2023; 2:50 pm

Mathematical modeling of hormonal contraception and the menstrual cycle

We review the current state-of-the-art in mathematical modeling of the menstrual cycle. We compare and contrast different modeling choices and the benefits and limitations of various models. We investigate the sensitivity of these models to variations in parameter values, highlighting that these models display particular sensitivity to the growth rate of [Read More...]

Presenter: Heather Zinn Brooks, Harvey Mudd College
Authors: Lihong Zhao, Ruby Kim, Lucy S. Oremland, Mukti Chowkwale, Lisette G. de Pillis, and Heather Z. Brooks
Symposium Year: 2023
Session: Promoting children's and women's health with mathematical and computational approaches [Organized by Karin Leiderman and Anna Nelson]
Presentation Time: October 1, 2023; 3:15 pm